On-Demand Webinar | Spatial Transcriptomics in KRAS-Driven Lung Cancer

In this webinar, Dr. Mukesh Nyati (University of Michigan) and Dr. Marco Corbo (Signios Bio) explore how spatial transcriptomics reveals localized resistance mechanisms in KRAS-driven lung cancers.

You'll hear how spatial analysis brings new clarity to tumor heterogeneity, EGFR-targeting strategies, and immune response—all through real data from preclinical models.

What’s covered:
• Spatial patterns in KRAS-driven lung tumors
• Tumor-immune interactions uncovered with spatial data
• A new EGFR degrader and implications for therapy resistance

Mukesh Nyati is a Professor in the Department of Radiation Oncology at the University of Michigan Medical School. He joined the department as a post-doctoral fellow in 1999 and has since focused his research on cancer therapeutics. For over a decade, his work has explored methods to degrade activated-EGFR to develop treatments for EGFR-driven, drug-resistant cancers, in collaboration with Dvant Pharma, a University of Michigan spin-out he founded. His research has secured a several NIH or DOD grants and multiple international patents. Nyati contributes to the University of Michigan through roles in the Faculty Senate Assembly, Biomedical Research Council, Rogel Cancer Center Innovation Program, and Carbon Neutrality and Sustainability Council.
He also mentors students and organizes the Cancer Biology Course for Radiation Oncology residents. Outside academia, Nyati volunteers for cancer awareness and charitable causes, supporting these efforts through his photography.

Marco Corbo is a scientist who has been driven by an interest in the study of genomics, chromosomal evolution and epigenomics. His main projects have focused on single cell analysis, bulk/single cell multiomics and pipeline development. At Signios Bio, Marco is a Senior Scientist and the Director of Bioinformatics, where he builds tools and pipelines to analyze large amounts of omics data to aid researchers in drug development and precision medicine. He received his BS in Biology and from the Università degli Studi di Palermo. He earned his MS degree in Molecular Biology and Genetics and his PhD from the University of Pavia in Lombardy, Italy. His postdoctoral work was completed at
UC Davis, where he focused on identification of mammalian chromosomal chromatin three-dimensional structures and their inheritance in the mammalian phylogenetic tree.